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Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A
Exosomes are small cellular vesicles that carry various metabolites across the cell membrane. Exosomes secreted by cancer tumor cells often contribute to metastasis and progression of disease. Scientists have discovered that sulfisoxazole, an FDA-approved antibiotic, inhibits small exosome secretion in breast..
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Phase III HEAT Study Adding Lyso-Thermosensitive Liposomal Doxorubicin to Radiofrequency Ablation in Patients with Unresectable Hepatocellular Carcinoma Lesions
Hepatocellular carcinoma (HCC) is an aggressive type of liver cancer. Radiofrequency ablation (RFA) is used as a curative treatment for early-stage HCC. RFA alone may however, result in recurrent cancer caused by residual viable cancer cells. Lyso-thermosensitive liposomal doxorubicin (LTLD) releases a high c..
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An ultrasensitive photoelectrochemical biosensor for glucose based on bioderived nitrogen-doped carbon sheets wrapped titanium dioxide nanoparticles
Photoelectrochemical (PEC) biosensing is a highly sensitive and cost-effective technique compared to other optical biosensing methods that require sophisticated optical instruments and data processing software. Traditional nanomaterial-based sensors, however, show poor conductivity. Addressing this issue in a..
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A phase 3 study of nivolumab in previously treated advanced gastric or gastroesophageal junction cancer (ATT RAC TION‑2): 2‑year update data
Gastric/gastroesophageal junction (G/GEJ) cancer is one of the most common cancers worldwide with a remarkably high prevalence in East Asian countries, including Japan and Korea. Nivolumab, an immune checkpoint inhibitor, has been approved as a third-line therapy for the treatment of heavily pre-treated G/GEJ..
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Recent Progress on the Sensing of Pathogenic Bacteria Using Advanced Nanostructures
Pathogenic bacteria are the causative agents for several diseases and are transmitted through various routes including water, food, and biological samples. Recent advances in nanotechnology have led to the development of several nanomaterial-based sensors that can detect single or multiple pathogenic bacteria..
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Ti3C2Tx MXene core-shell spheres for ultrahigh removal of mercuric ions
Adsorption is a safe and effective strategy for the removal of heavy metal contaminants from water. Conventional titanium carbide (Ti3C2Tx) nanocomposites have shown promise in heavy metal decontamination but lack stability, limiting their use in long-term applications. In a recent study published in the Chem..
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Executive Summary of Stroke Statistics in Korea 2018: A Report from the Epidemiology Research Council of the Korean Stroke Society
Stroke is the second most common cause of death and the third most common cause of disability worldwide. Although stroke contributes significantly to the disease burden in Korea, stroke incidence has not been well documented. To this end, the Epidemiologic Research Council of the Korean Stroke Society launche..
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An Update on in Vivo Imaging of Extracellular Vesicles as Drug Delivery Vehicles
Extracellular vesicles (EVs) are nanovesicles secreted by various types of cells. They are considered as a medium of inter-cellular communication and are now being increasingly explored as drug delivery vehicles for the treatment of cancers and other diseases. Tracking EVs in vivo is essential to ensure effec..
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Gene regulation of mammalian long non‑coding RNA
Only 2% of transcribed RNA is translated into proteins. A major proportion of RNA generated in a cell that is not translated into protein is known as long non-coding RNA (ncRNA). Over the last two decades, the functions of ncRNAs have been increasingly explored. A review article published in Molecular Genetic..